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dc.contributor.authorSchutte, Rudolph
dc.contributor.authorSchutte, Aletta E.
dc.contributor.authorHuisman, Hugo W.
dc.contributor.authorVan Rooyen, Johannes M.
dc.contributor.authorMalan, Nicolaas T.
dc.contributor.authorSzabolcs, Péter
dc.contributor.authorFourie, Carla M.T.
dc.contributor.authorVan der Westhuizen, Francois H.
dc.contributor.authorLouw, Roan
dc.contributor.authorBotha, Cindy A.
dc.contributor.authorMalan, Leoné
dc.identifier.citationSchutte, R. et al. 2009. Blood glutathione and subclinical atherosclerosis in African men: the SABPA study. American journal of hypertension, 22(11):1154-1159. []en_US
dc.identifier.issn1941-7225 (Online)
dc.description.abstractBackground: Sub-Saharan Africans face an increasing burden of hypertension and related cardiac and cerebrovascular morbidity and mortality, making the identification of factors leading to early vascular abnormalities imperative. Methods: We investigated the possible influence of the antioxidant glutathione (GSH) on early subclinical atherosclerosis in 63 hypertensive (aged 45.2 years) and 34 normotensive (aged 38.9 years; P < 0.001) nondiabetic African men. We measured ambulatory daytime systolic and diastolic blood pressure (SBP, DBP) as well as daytime mean arterial pressure (MAP), carotid intima-media thickness (CIMT), and calculated the cross-sectional wall area.We determined the reduced form of GSH in whole blood and blood glucose in serum. Results: Blood glucose (110 vs. 92 mg/dl; P < 0.001) and CIMT (0.75 vs. 0.61 mm; P < 0.001) were higher in hypertensives compared to normotensives. No significant difference existed for GSH. Associations in normotensives suggested the hypotensive effect of GSH after single (SBP: r = ―0.35,P ≤ 0.05; DBP: r=-0.37, P ≤ 0.05; MAP: r=-0.38, P ≤ 0.05) and multiple (SBP: B = ―0.015, P < 0.05; DBP: B = ―0.011, P < 0.05; MAP: B = ―0.012, P < 0.05) regression analyses. In hypertensives, CIMT (B = ―0.00027, P < 0.01) and cross-sectional wall area (CSWA) (B = ―0.0066, P < 0.05) correlated negatively with GSH.These findings were consistent after excluding 10 human immunodeficiency virus (HIV)-positive hypertensive subjects. Conclusions: In hypertensive African men, CIMT is negatively associated with GSH, suggesting a possible contributory role of attenuated GSH levels in the development of subclinical atherosclerosis.
dc.publisherOxford Univ Press
dc.subjectvascular diseases
dc.subjectblood glucose
dc.subjectwhole blood
dc.subjectdiastolic blood pressure
dc.subjectmean arterial pressure
dc.subjectcarotid intima-media thickness
dc.titleBlood glutathione and subclinical atherosclerosis in African men: the SABPA studyen_US
dc.contributor.researchID10986707 - Louw, Roan
dc.contributor.researchID10213503 - Van der Westhuizen, Francois Hendrikus
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia

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