dc.contributor.author | Mdlophane, A.H. | |
dc.contributor.author | Zeevaart, J.R. | |
dc.contributor.author | Ebenhan, T. | |
dc.contributor.author | Marjanovic-Painter, B. | |
dc.contributor.author | Govender, T. | |
dc.date.accessioned | 2019-09-06T08:25:18Z | |
dc.date.available | 2019-09-06T08:25:18Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Mdlophane, A.H. et al. 2019. Comparison of DOTA and NODAGA as chelates for 68Ga-labelled CDP1 as novel infection PET imaging agents. Journal of radioanalytical and nuclear chemistry, 322(2):629-638. [https://doi.org/10.1007/s10967-019-06693-5] | en_US |
dc.identifier.issn | 0236-5731 | |
dc.identifier.issn | 1588-2780 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/33285 | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s10967-019-06693-5 | |
dc.identifier.uri | https://doi.org/10.1007/s10967-019-06693-5 | |
dc.description.abstract | The cathelicidin-derived peptide (CDP1) is a human antimicrobial peptide that preferentially targets bacterial membranes in response to infection. CDP1 was functionalised with NODAGA and DOTA for complexation with gallium-68 to evaluate its potential as an infection imaging tracer. The synthesis of [68Ga]Ga–NODAGA–CDP1 and [68Ga]Ga–DOTA–CDP1 were optimised for pH, molarity, incubation time and temperature, and product purification. The integrity and protein binding were investigated employing [68Ga]GaCl3 and [68Ga]Ga–DOTA–TATE as internal references. [68Ga]Ga–NODAGA–CDP1 displayed good labelling properties with higher product yield compared to [68Ga]Ga–DOTA–CDP1. In contrast, [68Ga]Ga–DOTA–CDP1 showed better stability and is the preferred candidate for an in vivo investigation | en_US |
dc.language.iso | en | en_US |
dc.publisher | Springer | en_US |
dc.subject | CDP1 | en_US |
dc.subject | NODAGA | en_US |
dc.subject | 68Ga | en_US |
dc.subject | Antimicrobial peptides | en_US |
dc.subject | Infection imaging | en_US |
dc.subject | PET | en_US |
dc.title | Comparison of DOTA and NODAGA as chelates for 68Ga-labelled CDP1 as novel infection PET imaging agents | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 16951484 - Zeevaart, Jan Rijn | |