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dc.contributor.authorVan Staden, C.
dc.contributor.authorDe Brouwer, G.
dc.contributor.authorBotha, T.L.
dc.contributor.authorBrand, S.J.
dc.contributor.authorWolmarans, D.
dc.date.accessioned2020-01-24T13:00:44Z
dc.date.available2020-01-24T13:00:44Z
dc.date.issued2020
dc.identifier.citationVan Staden, C. et al. 2020. Dopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug action. Behavioural brain research, 379: #112393. [https://doi.org/10.1016/j.bbr.2019.112393]en_US
dc.identifier.issn0166-4328
dc.identifier.issn1872-7549 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/33950
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0166432819314573
dc.identifier.urihttps://doi.org/10.1016/j.bbr.2019.112393
dc.description.abstractCognitive flexibility, shown to be impaired in patients presenting with compulsions, is dependent on balanced dopaminergic and serotonergic interaction. Towards the development of a zebrafish (Danio rerio) screening test for anti-compulsive drug action, we manipulated social reward appraisal under different contexts by means of dopaminergic (apomorphine) and serotonergic (escitalopram) intervention. Seven groups of zebrafish (n = 6 per group) were exposed for 24 days (1 h per day) to either control (normal tank water), apomorphine (50 or 100 μg/L), escitalopram (500 or 1000 μg/L) or a combination (A100/E500 or A100/E1000 μg/L). Contextual reward appraisal was assessed over three phases i.e. Phase 1 (contingency association), Phase 2 (dissociative testing), and Phase 3 (re-associative testing). We demonstrate that 1) sight of social conspecifics is an inadequate motivational reinforcer under circumstances of motivational conflict, 2) dopaminergic and serotonergic intervention lessens the importance of an aversive stimulus, increasing the motivational valence of social reward, 3) while serotoninergic intervention maintains reward directed behavior, high-dose dopaminergic intervention bolsters cue-directed responses and 4) high-dose escitalopram reversed apomorphine-induced behavioral inflexibility. The results reported here are supportive of current dopamine-serotonin opponency theories and confirm the zebrafish as a potentially useful species in which to investigate compulsive-like behaviorsen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectObsessive-compulsive disorderen_US
dc.subjectZebrafishen_US
dc.subjectDopamineen_US
dc.subjectSerotoninen_US
dc.subjectInflexibilityen_US
dc.subjectOpponencyen_US
dc.titleDopaminergic and serotonergic modulation of social reward appraisal in zebrafish (Danio rerio) under circumstances of motivational conflict: towards a screening test for anti-compulsive drug actionen_US
dc.typeArticleen_US
dc.contributor.researchID23511990 - De Brouwer, Geoffrey
dc.contributor.researchID26964546 - Botha, Tarryn Lee
dc.contributor.researchID20279477 - Brand, Sarel Jacobus
dc.contributor.researchID12324515 - Wolmarans, Petrus De Wet


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