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dc.contributor.authorWentzel, Annemarie
dc.contributor.authorMalan, Leoné
dc.contributor.authorVon Känel, Roland
dc.contributor.authorMalan, Nicolaas T.
dc.date.accessioned2020-03-05T10:58:56Z
dc.date.available2020-03-05T10:58:56Z
dc.date.issued2019
dc.identifier.citationWentzel, A. et al. 2019. Ethnicity-specific changes in cardiac troponin t in response to acute mental stress and ethnicity-specific cutpoints for the R wave of the aVL lead: the SABPA study. American journal of epidemiology, 188(8):1444-1455. [https://doi.org/10.1093/aje/kwz082]en_US
dc.identifier.issn0002-9262
dc.identifier.issn1476-6256 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/34256
dc.identifier.urihttps://academic.oup.com/aje/article/188/8/1444/5423752
dc.identifier.urihttps://doi.org/10.1093/aje/kwz082
dc.description.abstractAcute mental stressor–induced cardiac stress responses might contribute to excessive myocardial strain and resultant cardiovascular episode risk. We assessed ethnicity-specific acute cardiac stress (by measuring cardiac troponin T (cTnT) and N-terminal prohormone of brain natriuretic peptide) related to hemodynamic activity. The prospective Sympathetic Activity and Ambulatory Blood Pressure in Africans (SABPA) study was conducted during 2007–2008 in South Africa. In the cross-sectional phase of the SABPA study, 388 black and white participants underwent a 1-minute acute mental stressor, during which blood pressure was continuously measured. Fasting blood samples for cardiac stress markers were obtained before and 10 minutes after stress (% change). Resting 10-lead electrocardiogram measured the R wave of the aVL lead (RaVL). Black participants exhibited greater cardiac stress responses (P < 0.001), diastolic blood pressure, total peripheral resistance, and stroke volume compared with white participants, who displayed decreases in cardiac stress and increases in cardiac output. Prestress and stressor cTnT cutpoints of 4.2 pg/mL predicted 24-hour, daytime, and nighttime diastolic hypertension in black participants (P < 0.001). These cTnT cutpoints were associated with an ethnicity-specific RaVL cutpoint of 0.28 mV (odds ratio = 3.49, 95% confidence interval: 2.18, 5.83; P = 0.021). Acute mental stress elicited an α-adrenergic activation pattern and cardiac stress hyperreactivity only in black participants. Mental stress might increase the black population’s risk for ischemic episodes and heart diseaseen_US
dc.language.isoenen_US
dc.publisherOxford Univ Pressen_US
dc.subjectAfricansen_US
dc.subjectMental stressen_US
dc.subjectRaVLen_US
dc.subjectTroponin Ten_US
dc.subjectRace/ethnicityen_US
dc.titleEthnicity-specific changes in cardiac troponin t in response to acute mental stress and ethnicity-specific cutpoints for the R wave of the aVL lead: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID23615109 - Wentzel, Annemarie
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID25499777 - Von Känel, Roland


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