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dc.contributor.authorBay, Vibeke
dc.contributor.authorWegener, Gregers
dc.contributor.authorHapp, Denise F.
dc.contributor.authorArdalan, Maryam
dc.contributor.authorQuist, Alexandra
dc.date.accessioned2020-04-06T08:42:05Z
dc.date.available2020-04-06T08:42:05Z
dc.date.issued2020
dc.identifier.citationBay, V. et al. 2020. Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery. Brain research, 1737:#146797. [https://doi.org/10.1016/j.brainres.2020.146797]en_US
dc.identifier.issn0006-8993
dc.identifier.urihttp://hdl.handle.net/10394/34505
dc.identifier.urihttps://www.sciencedirect.com/science/article/abs/pii/S0006899320301530
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2020.146797
dc.description.abstractBackground Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The underlying mechanisms linking depression and stroke remain unclear. Preclinical models may provide novel insights, but models reflecting both conditions are lacking. Methods In this study, we investigated the effects of a 45-min transient middle cerebral artery occlusion (MCAo) on infarct size in male adult Flinders Sensitive Line rats, a genetic animal model of depression, and their control strains Flinders Resistant Line and Sprague-Dawley rats. Infarct size was assessed by tetrazolium chloride (TTC) and microtubule-associated protein 2 (MAP2) staining after 48 h of reperfusion. Angiograms of the vascular structure of naïve animals were produced with a µ-CT scanner. Results Both Flinders strains had significantly smaller infarcts following MCAo compared to Sprague-Dawley rats. This effect does not appear to be due to changes in cerebrovascular architecture, as indicated by an initial exploration of vascular organization using angiograms, or body temperature regulation. Conclusions Our study suggests that the rat strain does not influence infarct volumes following MCAoen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectFlinders sensitive lineen_US
dc.subjectDepressionen_US
dc.subjectStrokeen_US
dc.subjectMCAoen_US
dc.subjectTTCen_US
dc.titleFlinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral arteryen_US
dc.typeArticleen_US
dc.contributor.researchID22353003 - Wegener, Gregers


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