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dc.contributor.authorTanner, Lloyd
dc.contributor.authorHaynes, Richard K.
dc.contributor.authorWiesner, Lubbe
dc.date.accessioned2020-06-11T12:15:43Z
dc.date.available2020-06-11T12:15:43Z
dc.date.issued2020
dc.identifier.citationTanner, L. et al. 2020. Accumulation of TB-active compounds in murine organs relevant to infection by mycobacterium tuberculosis. Frontiers in pharmacology, 11: #724. [https://doi.org/10.3389/fphar.2020.00724]en_US
dc.identifier.issn1663-9812 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/34761
dc.identifier.urihttps://www.frontiersin.org/articles/10.3389/fphar.2020.00724/pdf
dc.identifier.urihttps://doi.org/10.3389/fphar.2020.00724
dc.description.abstractTuberculosis (TB), the leading cause of death due to an infectious agent, requires prolonged and costly drug treatments. With the rise in incidence of MDR and XDR TB, newer more efficacious treatments which are better able to permeate into the deeper recesses of the human lung where bacteria reside are urgently required. To this end, two new promising drug candidates, the decoquinate derivative RMB041 and the phenoxazine PhX1, were assessed for their abilities to permeate into specific murine organs. In particular, PhX1 permeation into the lungs and heart was notably efficient, as reflected in the high relative AUC values of 9669 ± 120.2 min/nmol/mg and 12450 ± 45.2 min/nmol/mg for lung and heart tissue, respectively. However, neither compound maintained a free concentration in the lung which exceeded the compound’s respective MIC90 values, indicating the importance of correcting for organ specific bindingen_US
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.subjectorgan concentrations, tuberculosis, tuberculosis chemotherapy, decoquinate, phenoxazine, liquid chromatography-tandem mass spectrometryen_US
dc.subjectOrgan concentrationsen_US
dc.subjectTuberculosisen_US
dc.subjectTuberculosis chemotherapyen_US
dc.subjectDecoquinateen_US
dc.subjectPhenoxazineen_US
dc.subjectLiquid chromatography-tandem mass spectrometryen_US
dc.titleAccumulation of TB-active compounds in murine organs relevant to infection by mycobacterium tuberculosisen_US
dc.typeArticleen_US
dc.contributor.researchID22966390 - Haynes, Richard Kingston


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