dc.contributor.author | Beteck, Richard M. | |
dc.contributor.author | Van der Kooy, Frank | |
dc.contributor.author | Legoabe, Lesetja J. | |
dc.contributor.author | Jordaan, Audrey | |
dc.contributor.author | Swart, Tarryn | |
dc.date.accessioned | 2020-08-06T13:56:25Z | |
dc.date.available | 2020-08-06T13:56:25Z | |
dc.date.issued | 2020 | |
dc.identifier.citation | Beteck, R.M. et al. 2020. 6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity. Chemical biology & drug design, (In press). [https://doi.org/10.1111/cbdd.13747] | en_US |
dc.identifier.issn | 1747-0277 | |
dc.identifier.issn | 1747-0285 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/35507 | |
dc.identifier.uri | https://onlinelibrary.wiley.com/doi/abs/10.1111/cbdd.13747 | |
dc.identifier.uri | https://doi.org/10.1111/cbdd.13747 | |
dc.description.abstract | In this study, we synthesized novel nitro quinolone‐based compounds and tested them in vitro against a panel of Gram‐positive and Gram‐negative pathogens including Mycobacterium tuberculosis (MTB), Pseudomonas aeruginosa , Acinetobacter baumannii , Klebsiella pneumonia , Staphylococcus aureus , and Escherichia coli for antibacterial activities and also against HeLa cells for overt cytotoxicity. Compound 8e was identified as a non‐toxic, potent hit with selective activity (MIC90 ˂ 0.24 µm ) against MTB. 8e , however, showed no activity against DprE1 mutant, suggesting DprE1 as the likely target for this compound class | en_US |
dc.language.iso | en | en_US |
dc.publisher | Wiley | en_US |
dc.subject | DprE1 enzyme | en_US |
dc.subject | Mycobacterium tuberculosis | en_US |
dc.subject | Nitro drugs | en_US |
dc.subject | Quinolones | en_US |
dc.title | 6-Nitro-1-benzylquinolones exhibiting specific antitubercular activity | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 25159194 - Beteck, Richard Mbi | |
dc.contributor.researchID | 34406786 - Van der Kooy, Frank | |
dc.contributor.researchID | 12902608 - Legoabe, Lesetja Jan | |