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dc.contributor.authorKannigadu, Christina
dc.contributor.authorAucamp, Janine
dc.contributor.authorN'Da, David D.
dc.date.accessioned2020-11-26T10:14:41Z
dc.date.available2020-11-26T10:14:41Z
dc.date.issued2020
dc.identifier.citationKannigadu, C. et al. 2020. Synthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazide. Drug development research, (In press). [https://doi.org/10.1002/ddr.21755]en_US
dc.identifier.issn0272-4391
dc.identifier.issn1098-2299 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/36459
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/ddr.21755
dc.identifier.urihttps://doi.org/10.1002/ddr.21755
dc.description.abstractLeishmaniasis is a vector‐borne parasitic disease that mostly affects populations in tropical and subtropical countries. There is currently no vaccine to protect against and only a handful of drugs are available to treat this disease. Leishmaniasis is curable, but its eradication and elimination are hindered by the emergence of multidrug resistant strains of the causative pathogens, accentuating the need for new and effective antileishmanial drugs. In search for such agents, nifuroxazide, a clinical antibiotic, was evaluated through investigation of its benzyl analogues for in vitro antileishmanial efficacy against promastigotes of various Leishmania (L.) strains. The monobenzylated analogues 1 and 2 were the most potent of all, possessing nanomolar activities up to 10‐fold higher than the parent drug nifuroxazide against all three tested Leishmania strains. Both analogues stand as antipromastigote hits for further lead investigation into their potential to act as new antileishmanial agents.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectCytotoxicityen_US
dc.subjectIn vitroen_US
dc.subjectLeishmaniasisen_US
dc.subjectNifuroxazideen_US
dc.subjectNitrofuranen_US
dc.subjectPromastigoteen_US
dc.titleSynthesis and in vitro antileishmanial efficacy of benzyl analogues of nifuroxazideen_US
dc.typeArticleen_US
dc.contributor.researchID35159022 - Kannigadu, Christina
dc.contributor.researchID20505698 - Aucamp, Janine
dc.contributor.researchID20883072 - N'Da, David Dago


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