Influence of the composition of water/ethanol mixtures on the solubility and recrystallization of nevirapine

Abstract

Anhydrous nevirapine was recrystallized from ethanol containing various amounts of water to determine its effects on the products obtained. The solubility of the anhydrous form was determined for each of the binary solvent systems, and compared to the composition of the solvent system. A novel hemiethanolate was fully characterized by thermal methods, FT-IR spectroscopy, and single crystal X-ray diffraction