dc.contributor.author | N'Da, David D. | |
dc.contributor.author | Breytenbach, Jaco C. | |
dc.contributor.author | Smith, Peter J. | |
dc.contributor.author | Lategan, Carmen | |
dc.date.accessioned | 2012-09-03T09:32:38Z | |
dc.date.available | 2012-09-03T09:32:38Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | N'Da, D.D. et al. 2011. Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters. Arzneimittelforschung / Drug research, 61(6):358-365. [https://doi.org/10.1055/s-0031-1296211] | en_US |
dc.identifier.issn | 0004-4172 | |
dc.identifier.uri | http://hdl.handle.net/10394/7200 | |
dc.identifier.uri | https://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0031-1296211 | |
dc.identifier.uri | https://doi.org/10.1055/s-0031-1296211 | |
dc.description.abstract | New 4-aminoquinoline-derived esters containing the redox-active ferrocene group brought in by either ferrocenyformic or 4-ferrocenylbutanoic acids were synthesized and tested in vitro for their antiplasmodial activity. The results revealed that only esters derived from ferrocenylformic acid were active against both chloroquine (CQ)-resistant Dd2 and CQ-sensitive D10 strains of Plasmodium falciparum. However, none of these showed higher actvity than CQ against the sensitive strain. Ester 16, which possesses a butyl branch in the structure, was the most active of all. With an IC50 of 0.13 mM on the resistant strain, this ester possessed 2.5-fold higher activity than CQ (IC50 = 0.34 mM). All tested esters showed good selectivity towards P. falciparum with indexes higher than 60. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Thieme | en_US |
dc.subject | Antiplasmodial activity | |
dc.subject | Chloroquin | |
dc.subject | Cytotoxicity | |
dc.subject | Ferrocene | |
dc.subject | Plasmodium falciparum | |
dc.title | Synthesis and in vitro antiplasmodial activity of quinoline-ferrocene esters | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 20883072 - N'Da, David Dago | |
dc.contributor.researchID | 10059768 - Breytenbach, Jaco Cornelius | |