dc.contributor.author | Slabbert, C. | |
dc.contributor.author | Kotzé, A.F. | |
dc.contributor.author | Du Plessis, L.H. | |
dc.date.accessioned | 2012-10-19T14:24:47Z | |
dc.date.available | 2012-10-19T14:24:47Z | |
dc.date.issued | 2011 | |
dc.identifier.citation | Slabbert, C. et al. 2011. Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine. International journal of pharmaceutics, 409(1-2):209-215. [https://doi.org/10.1016/j.ijpharm.2011.01.050] | en_US |
dc.identifier.issn | 0378-5173 | |
dc.identifier.issn | 1873-3476 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/7533 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517311000810 | |
dc.identifier.uri | https://doi.org/10.1016/j.ijpharm.2011.01.050 | |
dc.description.abstract | Stability data is used to determine the change the product has undergone over a certain time period at specific temperatures. In the present study, the physical stability characterized by size, pH and entrapment efficacy of mefloquine loaded liposomes and Pheroid™ vesicles were investigated. Size was accurately determined by flow cytometry. Entrapment efficacy, after unentrapped drug was removed was successfully determined by UV-spectrophotometry. The formulations contained 0.5% (m/v) mefloquine and results showed that mefloquine interfered with the formation of lipid bilayer of the liposomes. Liposomes increased in size from 5.22 ± 0.03 μm to 9.71 ± 1.11 μm with accelerated stability and large aggregates were observed. A notable difference in stability testing of Pheroid™ vesicles was seen with no significant increase in size. Entrapment efficacy of 68.72 ± 0.04% (5 °C), 67.45 ± 2.92% (25 °C) and 67.45 ± 2.92% (30 °C) were obtained at the different storage conditions. With these findings the mefloquine loaded Pheroid™ vesicles are stable and should be used investigated for the possible increase in efficacy and bioavailability and decrease toxicity. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Liposome | en_US |
dc.subject | Pheroid™ technology | en_US |
dc.subject | Mefloquine hydrochloride | en_US |
dc.subject | Stability characterization | en_US |
dc.subject | Drug delivery system | en_US |
dc.title | Evaluation of the physical properties and stability of two lipid drug delivery systems containing mefloquine | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 10200142 - Kotzé, Abraham Frederik | |
dc.contributor.researchID | 11948388 - Du Plessis, Lissinda Hester | |