Browsing by Subject "HPLC"
Now showing items 1-10 of 16
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Antibiotic resistance in triclosan heterotrophic plate count bacteria from sewage water
(North-West University, 2015)The concentration of triclosan in antiseptics, disinfectants and preservatives in products exceeds the minimal lethal levels. Extensive use of triclosan and antibiotics results in bacterial resistance to their active ... -
The antioxidant properties of the methanol extract of Cotyledon orbiculata L. var orbiculata (Haw.) DC. Leaves
(North-West University, [2012])South Africa is a country of great diversity. Different climate zones and a host of different habitats make South Africa the perfect platform for rich floral diversity. This floral diversity lends itself to the study of ... -
The detection and quantification of biomolecules in biological sample matrices
(North-West University (South-Africa), 2019)In the bodies of living humans and animals, endogenous biomolecules, and in particular the chemical messengers, play an essential role in the maintenance and functionality of physiological processes (Daintith, 2008; Gault ... -
Determination of antibiotic residues in fish sold in the supermarkets around Mafikeng, North West Province
(North-West University (South Africa), 2019)Aquaculture production has grown in the past decade, leading to a concurrent substantial growth in the use of antibiotics by the industry. The primary aim of this study was to determine antimicrobial residue levels of ... -
Development of a stability indicating HPLC method for the Pheroid™ delivery system
(North-West University, 2010)Stability plays an important role in the development of a new drug product. High Performance Liquid Chromatography (HPLC) is considered a stability indicating method of analysis. It is widely used in the pharmaceutical ... -
The development of efavirenz and praziquantel amorphous solid dispersions
(North-West University (South-Africa), 2019)Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ... -
The development of ritonavir and pyrimethamine amorphous solid dispersions
(North-West University (South-Africa), 2021)Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ... -
Evaluation of antibiotic residues in raw meat using different analytical methods
(MDPI, 2017)Antibiotic residue in meat is a serious public health concern due to its harmful effects on consumer health. This study aimed at estimating the residue levels of four commonly used antibiotics in meat samples using three ... -
Evaluation of fungal and mycotoxin contamination of maize consumed in the North West Province of South Africa
(North-West University (South Africa), 2015)The North West province of South Africa ranks the second major maize producing region in the country after the Free State, South Africa. In the North West province, as is the case in much of the world, fungal and subsequent ... -
Genetic polymorphism in dextromethorphan metabolism by CYP2D6 and CYP3A4 enzyme isoforms
(North-West University, 2003)Most administered drugs are metabolised in the liver by Phase I enzymes and more importantly by the cytochrome P450 (CYP) system. The extent of first-pass metabolism is important in determining whether the drug will have ...