Browsing Research Output by Author "5293ca83-d329-4a0f-b97a-63fd71a41024"
Now showing items 1-4 of 4
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Cell-free DNA: preanalytical variables
Bronkhorst, Abel Jacobus; Aucamp, Janine; Pretorius, Piet J. (Elsevier, 2015)Since the discovery of cell-free DNA (cfDNA) in human blood, most studies have focused on diagnostic and prognostic uses of these markers for solid tumors. Except for some prenatal tests and BEAMing, cfDNA analysis has not ... -
A historical and evolutionary perspective on circulating nucleic acids and extracellular vesicles: circulating nucleic acids as homeostatic genetic entities
Aucamp, Janine; Bronkhorst, Abel Jacobus; Pretorius, Piet J. (Springer, 2016)The quantitative and qualitative differences of circulating nucleic acids (cirNAs) between healthy and diseased individuals have motivated researchers to utilize these differences in the diagnosis and prognosis of various ... -
Methodological variables in the analysis of cell-free DNA
Bronkhorst, Abel Jacobus; Aucamp, Janine; Pretorius, Piet J. (Springer, 2016)In recent years, cell-free DNA (cfDNA) analysis has received increasing amounts of attention as a potential non-invasive screening tool for the early detection of genetic aberrations and a wide variety of diseases, especially ... -
A quantitative assessment of cell-free DNA utilizing several housekeeping genes: measurements from four different cell lines
Aucamp, Janine; Bronkhorst, Abel Jacobus; Wentzel, Johannes F.; Pretorius, Piet J. (Springer, 2016)Quantitative real-time PCR (qPCR) is regularly used to quantify cell-free nucleic acids (cfNAs) in order to identify biomarkers for various pathologies. However, studies have shown notable housekeeping gene expression ...