Browsing Research Output by Author "Elfving, Betina"
Now showing items 1-17 of 17
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Chronic restraint stress increases the protein expression of VEGF and its receptor VEGFR-2 in the prefrontal cortex
Elfving, Betina; Wegener, Gregers; Jakobsen, Jakob Lerche; Madsen, Jens Christian Bredahl; Müller, Heidi Kaastrup (Wiley, 2015)In the present study the central and peripheral regulation of VEGF, its cognate receptors, and regulators were examined after acute and chronic restraint stress in rats. After chronic restraint stress (6 h per day for 21 ... -
A critical role of mitochondria in BDNF-associated synaptic plasticity after one-week vortioxetine treatment
Chen, Fenghua; Wegener, Gregers; Danladi, Jibrin; Ardalan, Maryam; Elfving, Betina (Oxford Univ Press, 2018)Background Preclinical studies have indicated that antidepressant effect of vortioxetine involves increased synaptic plasticity and promotion of spine maturation. Mitochondria dysfunction may contribute to the pathophysiological ... -
Differential interaction with the serotonin system by S-ketamine, vortioxetine, and fluoxetine in a genetic rat model of depression
Du Jardin, Kristian Gaarn; Wegener, Gregers; Liebenberg, Nico; Müller, Heidi Kaastrup; Elfving, Betina (Springer, 2016)Rationale The mechanisms mediating ketamine’s antidepressant effect have only been partly resolved. Recent preclinical reports implicate serotonin (5-hydroxytryptamine; 5-HT) in the antidepressant-like action of ketamine. ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
Fryland, Tue; Wegener, Gregers; Elfving, Betina; Christensen, Jane H.; Mors, Ole (Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Electroconvulsive seizures regulates the Brd1 gene in the frontal cortex and hippocampus of the adult rat
Fryland, Tue; Wegener, Gregers; Elfving, Betina; Christensen, Jane H.; Mors, Ole; Fryland, Tue; Wegener, Gregers; Elfving, Betina; Christensen, Jane H.; Mors, Ole (Elsevier, 2012)Depressive disorders represent a significant health concern as they are associated with high social and physical dysfunction and increased risk for suicide. Electroconvulsive therapy (ECT) is the most effective treatment ... -
Gene expression related to serotonergic and glutamatergic neurotransmission is altered in the flinders sensitive line rat model of depression: effect of ketamine
Du Jardin, Kristian Gaarn; Wegener, Gregers; Müller, Heidi Kaastrup; Sanchez, Connie; Elfving, Betina (Wiley, 2017)Major depressive disorder (MDD) is associated with dysfunctional serotonergic and glutamatergic neurotransmission, and the genetic animal model of depression Flinders Sensitive Line (FSL) rats display alterations in these ... -
A gene-environment study of cytoglobin in the human and rat hippocampus
Hundahl, Christian Ansgar; Wegener, Gregers; Elfving, Betina; Müller, Heidi Kaastrup; Hay-Schmidt, Anders (PLoS, 2013)Background: Cytoglobin (Cygb) was discovered a decade ago as the fourth vertebrate heme-globin. The function of Cygb is still unknown, but accumulating evidence from in vitro studies point to a putative role in scavenging ... -
Isolation-induced behavioural changes in a genetic animal model of depression
Fischer, Christina W.; Wegener, Gregers; Liebenberg, Nico; Elfving, Betina; Lund, Sten (Elsevier, 2012)Depression is a heterogeneous disorder displaying a range of symptoms including feelings of despair and social withdrawal. Social isolation may complicate the progression of depression and have effects on both behaviour ... -
Ketamine and aminoguanidine differentially affect Bdnf and Mtor gene expression in the prefrontal cortex of adult male rats
Pereira, Vitor Silva; Wegener, Gregers; Elfving, Betina; Joca, Sâmia R.L. (Elsevier, 2017)The rapid and sustained antidepressant properties of ketamine provide evidence of the importance of the glutamatergic system in the neurobiology of depression. The antidepressant-like effects of ketamine are dependent on ... -
Maternal high-fat diet programs offspring emotional behavior in adulthood
Winther, Gudrun; Wegener, Gregers; Elfving, Betina; Müller, Heidi Kaastrup; Lund, Sten (Elsevier, 2018)Prenatal exposure to high-fat diet (HFD) might predispose offspring to develop metabolic and mental disorders later in life. Insight into the molecular and behavioral consequences of maternal HFD on offspring is sparse but ... -
The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour
Abildgaard, Anders; Wegener, Gregers; Elfving, Betina; Hokland, Marianne; Lund, Sten (Taylor & Francis, 2018)Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA). Objective: We ... -
Potential involvement of serotonergic signaling in ketamine's antidepressant actions: a critical review
Du Jardin, Kristian Gaarn; Wegener, Gregers; Müller, Heidi Kaastrup; Elfving, Betina; Dale, Elena (Elsevier, 2016)A single i.v. infusion of ketamine, classified as an N-methyl-d-aspartate (NMDA) receptor antagonist, may alleviate depressive symptoms within hours of administration in treatment resistant depressed patients, and the ... -
Probiotic treatment protects against the pro-depressant-like effect of high-fat diet in Flinders Sensitive Line rats
Abildgaard, Anders; Wegener, Gregers; Elfving, Betina; Hokland, Marianne; Lund, Sten (Elsevier, 2017)Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that ... -
Probiotic treatment reduces depressive-like behaviour in rats independently of diet
Abildgaard, Anders; Wegener, Gregers; Elfving, Betina; Hokland, Marianne; Lund, Sten (Elsevier, 2017)The gut microbiota has recently emerged as an important regulator of brain physiology and behaviour in animals, and ingestion of certain bacteria (probiotics) therefore appear to be a potential treatment for major depressive ... -
Rapid effects of S-ketamine on the morphology of hippocampal astrocytes and BDNF serum levels in a sex-dependent manner
Ardalan, Maryam; Wegener, Gregers; Elfving, Betina; Rafati, Ali H.; Mansouri, Monireh (Elsevier, 2020)The prevalence of major depressive disorder (MDD) is higher in women than men. Importantly, a differential behavioral response by sex to the antidepressant response to ketamine in rodents has been reported. Mechanistically, ... -
The schizophrenia and bipolar disorder associated BRD1 gene is regulated upon chronic restraint stress
Christensen, Jane H.; Wegener, Gregers; Elfving, Betina; Müller, Heidi K.; Fryland, Tue (Elsevier, 2012)Recent genetic evidence has implicated the bromodomain containing 1 gene (BRD1) with brain development and susceptibility to Schizophrenia and Bipolar Disorder. The BRD1 protein, which is essential for acetylation of histone ... -
A single dose of vortioxetine, but not ketamine or fluoxetine, increases plasticity-related gene expression in the rat frontal cortex
Du Jardin, Kristian Gaarn; Wegener, Gregers; Müller, Heidi Kaastrup; Sanchez, Connie; Elfving, Betina (Elsevier, 2016)Ketamine is a non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist that has been shown to induce a rapid antidepressant effect in treatment-resistant patients. Vortioxetine is a multimodal-acting antidepressant ...