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Herbal hepatotoxicity: current status, examples, and challenges
(Taylor & Francis, 2015)
Introduction: Herbal medicines have commonly been considered safe by the general public due to their natural origin and long history of traditional uses. In contrast to this belief, many plants produce toxic substances as ...
In vitro anti-cancer effects of artemisone nano-vesicular formulations on melanoma cells
(Elsevier, 2015)
Artemisone is a 10-amino-artemisinin derivative that is markedly superior in vitro and in vivo to current artemisinins against malaria and also possesses antitumor activity. In seeking to capitalise on the last property, ...
Topical delivery of 5-fluorouracil from Pheroid™ formulations and the in vitro efficacy against human melanoma
(Springer, 2015)
Drug delivery vehicles can influence the topical delivery and the efficacy of an active pharmaceutical ingredient (API). In this study the influence of Pheroid™ technology, which is a unique colloidal drug delivery system, ...
Development and validation of a LC-MS/MS method for the quantitation of lumefantrine in mouse whole blood and plasma
(Elsevier, 2015)
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed and validated for the quantitation of the antimalarial drug, lumefantrine (LF), in mouse whole blood and plasma. The analyte was extracted ...